Cancer cases may rise 6 times among women in 20 years

Sushmi Dey| TNN | Feb 4, 2017, 03.37 PM IST

Cancer cases may rise 6 times among women in 20 years (Getty Images)Cancer cases may rise 6 times among women in 20 years (Getty Images)
Incidence of cancer is projected to be six times more among women over the next two decades, mainly because of obesity , according to an assessment by Cancer Research, UK.Several of the obesity related cancers only affect women leading to a greater possibility of the disease among them. Besides obesity, smoking is also considered a significant reason for faster rate of cancer among women.

Cases of ovarian, cervical and oral cancers are predicted to rise the most, the analysis said. According to World Health Organisation (WHO), around one third of deaths from cancer are due to the five leading behavioural and dietary risks: high body mass index, low fruit and vegetable intake, lack of physical activity and to bacco and alcohol use.

The new data released by WHO, ahead of World Cancer Day on February 4, shows that the disease is now responsible for almost one in six deaths globally with around 8.8 million deaths from cancer reported every year. According to the UN agency , lowand middle-income countries account for two-thirds of cancer deaths as many of them lack early screening and basic treatment facilities for all.

Over 10 lakh new cases of cancer are diagnosed every year in India. However, due to late diagnosis over 7 lakh people die from the disease every year. Projections by Indian Council of Medical Research show India is likely to have over 17.3 lakh new cases of cancer and over 8.8 lakh deaths due to the disease by 2020.


At 14 times the safe limit, Gurgaon breathes fire

The city was blanketed in thick smog on a grey, brooding Wednesday that saw pollution levels reach nearly 14 times the safe standard. An overcast sky added to the general gloominess with visibility so poor that it completely engulfed the city’s impressive skyline and buildings as little as 200 metres away went beyond a cloak of haze.

Concentration of PM 2.5 touched the 800 mark in the afternoon, which was almost 14 times higher the national safe standard. The average 24-hour level of PM 2.5 (measured between 4pm on Tuesday and 4pm on Wednesday) was 423.62 micrograms per cubic metre (g m3), still seven times higher than the safe standard of 60.

According to officials at the Met department, the situation is going to get worse in the coming days. “If it doesn’t rain or wind speed doesn’t increase, the situation is likely to get worse. Better sunshine can also make a difference. It is expected that sunshine will be a little better on Sunday on wards,” said an official of Met department.

According to the data released by the CPCB, concentration of PM2.5 has constantly increased since Diwali (October 31). While the 24-hour average concentration of PM2.5 was 212.96gm3 on October 30 (from 2pm on October 29 to 2pm on October 30), it increased to 217.45gm3 on October 31. The level further rose to 328.15gm3 on November 1and reached 381.50gm3 on November 2. As per WHO, concentration of PM2.5 shouldn’t be more than 60gm3. However, other air pollutants such as carbon monoxide, sulphur dioxide, oxides of nitrogen and ozone remained below the prescribed limit.

While Haryana Pollution Control Board blamed rise in pollution in Delhi for conditions in Millennium City , experts said the authorities have not taken enough measures to deal with the problem, primarily by not being able to check stubble burning at farms.

“There are certain emergency measures which authorities should have taken after Gurgaon reported an increase in PM 2.5 concentration. These could have included closing down polluting industries for 15-20 days, reducing vehicular traffic, making changes in school timings ,” said Niranjan Raje, member of Environment Pollution (Prevention and Control) Authority (EPCA).

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Pluck hair in a specific pattern to grow new hair: Hair six times thicker in mice

Quorum sensing in hair population regeneration is shown.
Credit: Courtesy of Cheng-Ming Chuong

If there’s a cure for male pattern baldness, it might hurt a little. A team led by USC Stem Cell Principal Investigator Cheng-Ming Chuong has demonstrated that by plucking 200 hairs in a specific pattern and density, they can induce up to 1,200 replacement hairs to grow in a mouse. These results are published in the April 9 edition of the journal Cell.

“It is a good example of how basic research can lead to a work with potential translational value,” said Chuong, who is a professor of pathology at the Keck School of Medicine of USC. “The work leads to potential new targets for treating alopecia, a form of hair loss.”

The study began a couple of years ago when first author and visiting scholar Chih-Chiang Chen arrived at USC from National Yang-Ming University and Veterans General Hospital, Taiwan. As a dermatologist, Chen knew that hair follicle injury affects its adjacent environment, and the Chuong lab had already established that this environment in turn can influence hair regeneration. Based on this combined knowledge, they reasoned that they might be able to use the environment to activate more follicles.

To test this concept, Chen devised an elegant strategy to pluck 200 hair follicles, one by one, in different configurations on the back of a mouse. When plucking the hairs in a low-density pattern from an area exceeding six millimeters in diameter, no hairs regenerated. However, higher-density plucking from circular areas with diameters between three and five millimeters triggered the regeneration of between 450 and 1,300 hairs, including ones outside of the plucked region.

Working with Arthur D. Lander from the University of California, Irvine, the team showed that this regenerative process relies on the principle of “quorum sensing,” which defines how a system responds to stimuli that affect some, but not all members. In this case, quorum sensing underlies how the hair follicle system responds to the plucking of some, but not all ]hairs.

Through molecular analyses, the team showed that these plucked follicles signal distress by releasing inflammatory proteins, which recruit immune cells to rush to the site of the injury. These immune cells then secrete signaling molecules such as tumor necrosis factor alpha (TNF-α), which, at a certain concentration, communicate to both plucked and unplucked follicles that it’s time to grow hair.

“The implication of the work is that parallel processes may also exist in the physiological or pathogenic processes of other organs, although they are not as easily observed as hair regeneration,” said Chuong.

[“source -pcworld”