Three must-own cancer stocks for your biotechnology portfolio

June should be national cancer month.

Each year around this time, oncology groups and Wall Street brokerages hold a rash of conferences where researchers reveal the latest, greatest potential cancer cures.

This year has been no exception. Above all, we learned about remarkable advances in two exciting cancer therapies — and three great companies that will benefit.

Here’s more detail. (I’ve kept the technical language to a minimum.)

Cancer weapon

Tumors are smart. They know how to trick the immune system into missing them. But scientists are wising up to their tricks. In one evasive strategy, tumors release an enzyme that renders them invisible. If you block the enzyme, your immune system can find tumors and destroy them — with the help from cancer drugs. This is the key to an early-stage cancer weapon you should invest in, known as “IDO inhibitors.”

IDO stands for “Indoleamine 2,3-dioxygenase,” an enzyme released by tumors to blind the body’s immune system. “IDO is a strange drug target, because IDO inhibition by itself has no noticeable anti-cancer effect,” says Tanguy Seiwert, a cancer-therapy researcher and medical doctor who teaches at the University of Chicago. Suppressing IDO, however, makes tumors vulnerable.

The best “pure play” in IDO inhibitors is a company whose shares I own, and have suggested since December 2011 in my stock newsletter, Brush Up on Stocks. We’re up 750% in this company since 2011 ($14 to $120). But I think this stock is still a “hold” because there are bigger gains ahead.

Incyte Corp. INCY, +3.58% just released excellent data on its IDO inhibitor, called epacadostat, at the American Society of Clinical Oncology (ASCO) conference. In combination with cancer therapies from Merck & Co. MRK, +1.13%  and Bristol-Myers Squibb Co. BMY, +1.40% it showed excellent results against several kinds of cancer.

“It looks really good. I think this was a coming-out party for IDO inhibitors,” says Seiwert. Besides effectiveness, one of the main positives is that epacadostat is safe. This means it can be readily used to assist many other cancer drugs. “You can add it to a ton of things because the cost is low, in terms of toxicity.”

Incyte is an ideal biotech company for investors because it is self-funding. It has a very profitable drug called Jakafi, for a rare blood disorder, which supports research on new drugs like the IDO inhibitor. So investors dodge dilutive financings.

Fake news

So why hasn’t Incyte’s stock shot up? Investors have three main worries. But they look like false fears.

One bit of “fake news” circulating is that Incyte showed success, in part, only because it omitted patients from some results, which drove up the percentage of success stories. But this is a dubious critique for two reasons. Even if you included the three patients left out, it would only lower the success rate by a few percentage points, notes J.P. Morgan analyst Cory Kasimov. Second, Incyte offered several separate data sets showing success in many types of cancer, but the omission only affected one subgroup, says Seiwert. “I think this was way overblown.”

The next fear: Competitor NewLink Genetics Corp. NLNK, +3.27%   recently announced Roche AG RHHBY, +0.21%  handed back development rights to its IDO, following lousy results in a Roche study. Some investors take this as a sign that IDO is malarkey. But William Blair analyst Katherine Xu thinks this is bullish for Incyte, since it signals a competitor may be gone. NewLink’s IDO may have fared poorly because it works differently than Incyte’s IDO, or because Roche used an extremely sick patient population. Neither scenario reflects poorly on Incyte.

The third knock on Incyte is the one to watch. While Seiwert is impressed with Incyte’s IDO results, he points out the Phase II results are early-stage, and longer-term studies are needed to learn more about patient survival. Those studies are in the works. Incyte has nine Phase III studies planned with Merck and Bristol-Myers Squibb, says Xu. The outcomes here are key, since about $50 worth of the current $120 Incyte stock price is linked to IDO.

Turbo for the immune system

In another key advance in cancer therapy in the past two years, doctors have learned how to extract a patient’s blood and genetically tweak white blood cells so they override evasive tactics used by tumors.

Then the cells are reproduced in a lab to expand the supply, and put back in the patient’s body so they can move in for the kill. Hopefully, the cells then continue to proliferate and thrive and stay on hand to fight any more cancer that comes along.

Known as chimeric antigen receptor T-cell therapy (CAR-T), this approach has produced remarkable results against blood cancers in patients who otherwise had almost no hope of survival. CAR-T works by unblocking cancer cell receptors normally sought out by the immune system.

“This is one of the most exciting therapies in immunotherapy,” said Jae Park, a Memorial Sloan Kettering Cancer Center cancer researcher and medical doctor, at the Jefferies 2017 Global Healthcare Conference in early June.

Probably the best pure play here is Kite Pharma Inc. KITE, +1.64% At the Jefferies conference, Kite CEO Arie Belldegrun showed images of a patient’s body riddled with tumors, which disappeared about a month after treatment began. The patient showed no sign of the disease a year later.

Kite has a product coming on the market by the end of this year, and probably many more on the way, says Brad Loncar, the cancer research expert behind the Loncar Cancer Immunotherapy CNCR, +2.93%  exchange traded fund. This is pretty good progress for a therapy that was considered “science fiction” two years ago.

I suggested Kite in my stock letter at around $71 on May 17, and I think it’s still a “hold” even though it has already risen to $87, because this promises to be a blockbuster therapy. At the time, insiders were big buyers as the stock sold off on news of the death of a patient in one of its studies.

That unfortunate death highlights one of the key risks here. CAR-T patients have died because the therapy can cause brain swelling. Doctors are getting better at staving off adverse side effects, says Park. But they still don’t fully understand what causes them, which should raise a yellow flag for investors.

‘Impressive’ bluebird

Kite also faces competition from other companies developing CAR-T, including power players like Novartis AG NVS, +0.75% Pfizer Inc. PFE, +0.76% Johnson & Johnson JNJ, -0.21%  and GlaxoSmithKline PLC GSK, -0.09% as well as Juno Therapeutics Inc. JUNO, +3.91% Cellectis SA CLLS, +0.00% Adaptimmune Therapeutics PLC ADAP, -0.44% and two privately held companies called Poseida Therapeutics and Nanjing Legend Biotech.

Any of these efforts may pan out nicely, but my pick as a third CAR-T play is bluebird bio BLUE, +3.59% which is partnering with Celgene Corp. CELG, +2.29% Bluebird just announced really impressive results for its CAR-T candidate called bb2121. In early studies, just released at ASCO, this therapy produced an overall response rate of 90% to 100% among “hospice-type” patients whose cancer was so bad that seven different attempts to cure them, on average, had failed.

“To generate efficacy data on this level with an overall very tolerable safety profile is highly impressive,” says Kasimov, at J.P. Morgan. “With more key updates to come in 2017, we would continue to add to positions in bluebird bio.”

At the time of publication, Michael Brush held INCY. Brush has suggested INCY and KITE in his stock newsletter Brush Up on Stocks. Brush is a Manhattan-based financial writer who has covered business for the New York Times and The Economist group, and he attended Columbia Business School in the Knight-Bagehot program.

[“Source-ndtv”]

Chennai: Include three educational experts in the panel, directs HC

The PIL was filed by the director of an NGO, CHANGE India, A Narayanan

Director of an NGO, CHANGE India, A Narayanana filed the plea

Director of an NGO, CHANGE India, A Narayanana filed the plea

The state government has been directed to include three educational experts in the panel constituted by the government to deal with issues, including minimum land requirement, relating to 746 unauthorized schools.

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The court said the advocate general submitted that the norms have been worked out but conceded that the committee consists of only bureaucrats manning department persons concerned with education.

Directive of the HC: In brief

  • Since earlier recommendations included education experts also, it was agreed that three educational experts in the earlier committee could be included in this committee which may now finalize the report developed by the committee of bureaucrats
  • “We may note the submission of the counsel for the petitioner that the committee may keep in mind the observations made by the Supreme Court while dealing with Kumbakonam tragedy case,” the bench added
  • As per the earlier directive of the court, D Sabitha, Principal Secretary to Education department, was present in the court at the time of hearing.

About the PIL:

Who filed the PIL and why?

  • Earlier, Director of an NGO, CHANGE India, A Narayanan filed the PIL that sought to quash a government order dated August 18, 2015 of the school education secretary and consequently to forbear authorities from granting recognition against law to unrecognized schools not fulfilling the norms specified in various GOs and the judgment of the Supreme Court

What has been sought?

He also sought a direction to ensure that all unrecognized schools were closed by the end of the academic year 2015-16 and that students in such schools were placed in other neighbourhood government/government aided/unaided schools so as to enable them to continue their education in recognised schools.

.source”cnbc”

Prakash Javadekar launches ‘Sarthi’ at three Rajasthan centers on International Literacy Day

Union HRD miinister Prakash Javadekar inaugurated Sarthi at three centers, Churu, Chaksu and Udaipur in Rajasthan on International Literacy Day

On International Literacy Day, Union HRD Minister Prakash Javadekar inaugurated “Sarthi” at three centers, Churu, Chaksu and Udaipur in Rajasthan.

The program is likely to help the youth to get latest information on career opportunities and courses across the country.

Around 500 students in Churu, directly communicated with the minister as well as counsellors present at three locations.

This was the first time, HRD minister interacted with students: Read to know the minister’s reply

  • This was the first time, the minister interacted with students on the topic of higher education and career opportunities. He was joined by eminent educational and career counsellors
  • One student wanted the minister’s views on the “controversy related to high scoring by some state boards, like Tamil Nadu”, referring to students from the state getting admissions into the prestigious colleges of Delhi University
  • Replying to a student’s question, the minister said that the government is looking at instances such as these and was hoping to bring about some form of uniformity. “Don’t you think CBSE and state boards need a uniform syllabus,” he said.
  • “Since education is generally regarded as a slow-moving sphere of social policy, why has the ministry not been more pro-active?” in the reply, the minister said, “We are working towards bringing both qualitative and quantitative changes in education system.”

Vice President of Future Society makes some remarkable points:

  • “This initiative will help rural youth to join universities and will provide them a platform and a proper path to build carrier,” said, Future Society vice president Sushil Sharma
  • “Our effort will be to replicate this experiment on a larger scale both at the state and the national level.” he added.

View of Labour and Employment Minister of Rajasthan:

This project will certainly help in promoting the ‘Make in India and Skill India initiatives’, said Rajasthan Labour and Employment Minister Surender Pal Singh.

“Employment is a big problem for both rural and urban youth in the country. The reason for this is not only lack of opportunities but also lack of proper information. Sarthi hopes to bridge that gap,” a statement said.

source”gsmarena”

Gold’s run is achieved — appearance out for a $three hundred drop: Wells Fargo strategist

Gold

Gold is probable to move lower back to its lows, even after starting the year off with a bang, consistent withWells Fargo’s head of actual asset strategy, John LaForge.

His argument hinges on commodities tendencies that date again all of the way to 1800 and display what he calls “commodity undergo amazing cycles,” every of which lasts about twenty years. In the course of the bearish of those cycles, commodities like gold will tend to suffer negative performance, even as they retestcurrent highs and lows, according to LaForge.

He believes that a commodity undergo great cycle started in 2011. So while gold shot up to a 12 monthsexcessive of $1,357 on Tuesday, LaForge believes that the rally was predictable, and it is equally predictablethat a downturn is on its way.

We might been down for four years directly, so we wished a leap,” he said Tuesday on CNBC’s “TradingCountry.” “But the truth is that gold is a commodity, and commodities have entered a protracted undergomarketplace.”

Traditionally speakme, what normally happens while you enter those long bear markets for commodities isthey’ll cross lower back and retest their lows off of the first circulate down,” LaForge said.

For gold, meaning that the steel is probable to retest its December 2015 lows round $1,050, according toLaForge. At that stage, it may be an appealing buy.

That displays the approach LaForge would take when it comes to a bevy commodities, which includes oil.

“Oil is also caught in this long remarkable cycle,” he stated. “So I do not count on oil to go up a good dealbetter than $60.”

Gold is up 28 percentage in 2016, whilst WTI crude has risen 26 percentage.

Inside the real-asset universe, LaForge might shy away from those big bouncers and as a substitute favoractual property investments, given that “trendwise, they are doing the pleasant.”

OnePlus ditches invites for the OnePlus three

OnePlus co-founder Carl Pei disclosed that the OnePlus 3 will be launched invite-free right from releaseday. The agency goes to quickly announce the cellphone on June 14. He also reminded that the OnePlusthree might be available for buy exclusively through the Loop VR app during the primary two hours afterrelease. After that, anybody could be able to order one.

The OnePlus three’s specifications we realize to date consist of: 5.five-inch AMOLED 1080p display screen, go back of NFC help, Snapdragon 820 CPU paired with either 4GB or 6GB of RAM, 64GB of on-board garage, rear digital camera, a 3,000mAh battery, and a fingerprint scanner.

we will recognise all approximately the cellphone as soon as it is going reputable in much less thanweeks.

1 in three American malls are doomed: Retail representative Jan Kniffen

Pheasant Lane Mall

about one-third of yankee shops are not long for this global, retail analyst Jan Kniffen stated Thursday.

The CEO of J. Rogers Kniffen worldwide businesses spoke after Macy’s said its worst sequential samekeep income decline for the reason that economic crisis. Macy’s and different stores were givenslammed by way of a heat wintry weather and cool spring, as well as the continued migration of millennials to fast style and staleprice stores, Kniffen stated.

human beings walk beyond Macy’s flagship shop in manhattan, new york.
Macy’s dismal results deliver back reminiscences of the economic crisis
The effects are also a signal of the u . s .‘s oversupply of retail area at a time while trade is transferringonline, he brought.

“On an apples-to-apples basis, we’ve two times as plenty consistent with-capita retail space as some other vicinity within the international. The U.okay. is 2nd. they’re half of what we’re. So, sure, we are themost over-saved place in the world,” he instructed CNBC’s “Squawk box.”

With the U.S. having an expected forty eight square feet of retail space in step with citizen, the footprint is poised to say noquite speedy,” Kniffen said.

In his view, approximately 400 of the united states‘s 1,100 enclosed department shops will fail inside thecoming years. Of the survivors, approximately 250 will thrive and the rest will battle. Likewise, Macy’sprobable needs 500 of its more or less 800 existing stores, he stated.

He stated the mall owners and operators maximum probable to pop out on top are Taubman centers,standard growth partners and Simon property institution.

Asus pronounces ZenFone three, ZenFone 3 Deluxe, and ZenFone three extremely

Asus has announced the brand new ZenFone 3, ZenFone three Deluxe, and ZenFone 3 ultra at Computex 2016.

The Asus ZenFone 3 is the maximum basic version of the three. It has an aluminum body frame with 2.5D Corning Gorilla Glass at the front and back. at the front is a five.5-inch 1080p remarkable IPS+ show withup to 500 nits brightness and 77.3% display to body ratio.

The Zenfone 3 additionally has a sixteen megapixel camera at the again with ASUS TriTech autofocus that mixes 2nd era laser autofocus, section detection autofocus and comparison detection autofocus to attainrecognition in 0.03 seconds.

The handset runs on Qualcomm Snapdragon 625 and has up to 4GB of RAM. there’s additionally a fingerprint sensor on the again.

The ZenFone 3 Deluxe is the flagship version. It has a complete metal frame with no seen antenna tracesand 4.2mm edges. it is built around a five.7-inch first rate AMOLED display with over a hundred% NTSCcolor gamut and 79% screen to frame ratio.

The cellphone runs on the new Qualcomm Snapdragon 820 with up to 6GB of RAM. on the lower back is a 23 megapixel Sony IMX318 digicam with f2.0 aperture, 4-axis optical image stabilization, and 4K video with the equal TriTech autofocus gadget as on the ZenFone three.

The ZenFone 3 Deluxe uses a USB type-C connector with USB 3.zero and Qualcomm brief rate three.0 aid. The smartphone additionally has a fingerprint sensor on the back. lastly, there may be also a unmarried5-magnet speaker and hi-Res Audio assist.

subsequently, there is the ZenFone 3 extremely. It has a large 6.eight-inch 1080p show with 95% NTSCshade gamut help, 79% display to body ratio, and what ASUS calls Tru2Life+ Video generation that makes use of a excessiveend 4K UHD television-grade photograph processor. The ZenFone 3 additionally hasfive-magnet speakers, hello-Res Audio assist, and additionally the first cellphone to have digital 7.1 channel surround sound with DTS Headphone: X.

at the returned is the equal 23 megapixel digital camera as at the ZenFone three Deluxe. The phablet is powered by way of the Qualcomm Snapdragon 652 with as much as 4GB of RAM, and a 4600mAh battery with brief rate 3.0 assist.

The Zenfone 3 Deluxe also can charge different devices with a 1.5A output. lastly, there is a fingerprint sensor at the the front of the device. All packed in a complete steel body without a seen antenna strains.

expenses begin at $249 for the ZenFone 3, $499 for the ZenFone three Deluxe, and $479 for the ZenFonethree ultra.

Moto Z Droid Edition shows its back in leaked press renders, three color versions outed

It’s already been revealed that this year Motorola will unveil a successor each for the Moto X Style and Moto X Play from 2015, yet this time around they will bear Moto Z branding. While the Moto Z Style and Moto Z Play will be available internationally (and possibly unlocked in the US), let’s not forget about the company’s ongoing partnership with Verizon for Droid-branded handsets.

What you see below is the 2016 entry in the Droid hall of fame, the successor to the Droid Turbo 2 from 2015. It will probably be called Moto Z Droid Edition, and it’s likely to share its specs with the Moto Z Style.

It does share the looks of both the Z Style and Z Play, that’s for sure – at least on the back, as you can see above. Amazingly, the Droid branding is pretty discreet with this one, not something you’d expect from Verizon. Furthermore, Big Red’s own logo is nowhere to be seen, though it’s possible that it will be placed on the front of the device.

The Moto Z Droid Edition will support the MotoMods that Motorola will unveil this year. The company’s modular accessories connect to the pins that are present on the lower side of the phone’s back. The Droid will be offered in at least these three color versions – black, silver, and gold of course.

Spec-wise, if the Droid Edition borrows from the high-end Style, then expect it to sport the Snapdragon 820 chipset, along with 4GB of RAM, a 5.5-inch QHD AMOLED touchscreen, 32GB of storage, a 13 MP rear camera with OIS, and a 2,600 mAh battery, all packed into a 5.2mm thin body.

Moto Z Droid Edition shows its back in leaked press renders, three color versions outed

It’s already been revealed that this year Motorola will unveil a successor each for the Moto X Style and Moto X Play from 2015, yet this time around they will bear Moto Z branding. While the Moto Z Style and Moto Z Play will be available internationally (and possibly unlocked in the US), let’s not forget about the company’s ongoing partnership with Verizon for Droid-branded handsets.

What you see below is the 2016 entry in the Droid hall of fame, the successor to the Droid Turbo 2 from 2015. It will probably be called Moto Z Droid Edition, and it’s likely to share its specs with the Moto Z Style.

It does share the looks of both the Z Style and Z Play, that’s for sure – at least on the back, as you can see above. Amazingly, the Droid branding is pretty discreet with this one, not something you’d expect from Verizon. Furthermore, Big Red’s own logo is nowhere to be seen, though it’s possible that it will be placed on the front of the device.

The Moto Z Droid Edition will support the MotoMods that Motorola will unveil this year. The company’s modular accessories connect to the pins that are present on the lower side of the phone’s back. The Droid will be offered in at least these three color versions – black, silver, and gold of course.

Spec-wise, if the Droid Edition borrows from the high-end Style, then expect it to sport the Snapdragon 820 chipset, along with 4GB of RAM, a 5.5-inch QHD AMOLED touchscreen, 32GB of storage, a 13 MP rear camera with OIS, and a 2,600 mAh battery, all packed into a 5.2mm thin body.

Xiaomi sells 600,000 Redmi observe three gadgets

Xiaomi has announced that it has sold a complete of 600,000 Redmi notice three gadgets in India inside alength of 60 days. The assertion came inside the form of a fb publish from the chinese organisation‘s vice president Hugo Barra, who defined it as their “biggest document yet.”

The device become launched in India back in March this yr, wearing a rate tag of INR nine,999 ($148) for the 16GB version and INR eleven,999 ($178) for the 32GB version. And as you may already recognise, the modelavailable in India is powered via SD650.

The tool lately went on open sale within the u . s ., but become out of inventory within a couple of minutesmost effective.