Experimental gene-silencing drug from Alnylam and Sanofi shows strong results in hemophilia

Alnylam CEO John Maraganore aims to compete with what is expected to be a blockbuster hemophilia drug from Roche.

A

n experimental hemophilia drug developed by Alnylam Pharmaceuticals continues to staunch bleeding in patients followed for almost one year in an ongoing, mid-stage clinical trial, the company reported Monday.

The promising results could intensify an already heated competition to develop novel treatments for the inherited bleeding disorder. The Alnylam drug, developed in partnership with Sanofi, uses a technology called RNAi to shut down dysfunctional genes. It’s a promising approach that’s attracted billions in research dollars, but hasn’t yet been used in an actual drug approved for sale.

The company says the new data support its recent decision to advance its RNAi hemophilia drug —  known as fitusiran —  into phase 3 clinical trials. If it succeeds, the drug could potentially compete against an expected blockbuster hemophilia drug from Roche.

In the current study, 33 patients have been injected once a month with fitusiran. The results so far: 48 percent have not bled after a median observation period of 11 months, according to data reported Monday at the International Society of Thrombosis and Haemostasis Congress in Berlin. Some patients in the study have been followed for up to 20 months.

Before starting the study, patients were reporting a median of 20 bleeding events per year. That number was reduced to 1 following the fitusarin injections.

The patients have two types of the disease, hemophilia A and B. Fourteen of the patients have inhibitors —  immune system antibodies that interfere with clotting factors commonly used to treat hemophilia. Patients with inhibitors are the hardest to treat effectively.

For this group, the median annualized bleed rate fell from 38 to zero, although the median observation period was shorter at six months.

Sixty-four percent of the inhibitor patients have not bled since starting treatment with fitusiran.

“These are really encouraging numbers,” said Alnylam Chief Medical Officer Pushtal Garg, in a phone interview from Berlin on Sunday. “To show annual bleed rates of one and zero is remarkable, particularly for a treatment that is administered once per month with a subcutaneous, low-volume injection.”

One third of the fitusiran-treated patients in the study reported elevated liver enzymes, a possible signal of liver toxicity, though all these patients also had hepatitis C, Alnylam said. One patient with increased liver enzymes stopped participating in the study; the rest had no symptoms and their liver enzyme issues were resolved.

There were no blood clots reported by patients in the fitusiran study. That could help the drug stand apart from Roche’s hemophilia drug emicizumab, which had a handful of serious blood clots reported in its phase 3 studies.

Roche intends to submit emicizumab for approval this year to treat hemophilia A patients with inhibitors to standard therapy. Sixty-three percent of patients receiving emicizumab reported zero treated bleeds compared with 6 percent of patients treated with bypassing agents, according to phase 3 study results previously announced. (Those results were also presented Monday at the Berlin meeting and published in the New England Journal of Medicine.)

Some analysts have projected emicizumab’s peak sales could hit $2 billion per year for patients with inhibitors, although that figure is hotly debated given the drug’s blood clotting safety issue. This leaves a potential opening for fitusiran, though its phase 3 trial won’t report data until 2019.

The Roche drug may eventually have other competition, too. Biomarin Pharmaceuticals, Spark Therapeutics, and Uniqure are all developing gene therapies to treat — and potentially cure — hemophilia.

Hemophilia drug franchises from Shire and Novo Nordisk are at risk of losing billions of dollars in sales if these new hemophilia drugs are approved. Though there are just 20,000 patients with hemophilia in the U.S., it’s a highly lucrative market.

On Sunday, Shire took the unusual step of fighting back with a preliminary injunction from a German court against Roche. Shire accused Roche of disseminating “inaccurate and misleading” information about the safety and serious adverse events that occurred in the phase 3 clinical trial of emicizumab, according to Reuters. In a statement, Roche said it stood behind the emicizumab data.

Alnylam, which is based in Cambridge, Mass., develops drugs that work through a process called RNA interference, or RNAi. All of its drugs, including fitusiran, are snippets of genetic code known as RNA that turn off genes producing disease-causing proteins. Fitusiran blocks the production of antithrombin, a protein made in the liver that prevents blood from clotting. Monthly injections of fitusiran reduce antithrombin in patients and increase corresponding levels of thrombin, another protein that promotes blood clotting.

Last October, Alnylam shares fell sharply after another of its RNAi drugs caused more deaths than a placebo in a phase 3 study. Work on that drug was halted.

But Alnylam shares have recovered this year, up 125 percent to date, on renewed investor optimism for its late-stage drug pipeline, including another RNAi drug, patisiran, targeting a rare nerve disease.

At Friday’s $84.08 close, Alnylam carries an almost $8 billion market valuation. It doesn’t yet have a drug on the market, which means investors are giving the company a lot of credit already for its late-stage RNAi pipeline, including fitusarin.

[“Source-statnews”]

I Tried A Diet And Fitness Plan Based On My DNA And Couldn’t Believe The Results

 My name is Daysha, and I have always struggled with my weight.

Growing up, my weight fluctuated a lot. At one point in my life, I developed disordered eating habits. After recovering and practicing a lot of self-love, I found the problem then became that I never saw the same results that I did when I was starving myself.

It’s not that I don’t enjoy working out and eating healthy, because I do.

I love cooking healthy meals and I dance four to five times per week. I have always been frustrated with why it's so hard for me to lose weight. I tried all sorts of methods to lose weight and get fit, including a raw vegan diet, Weight Watchers, seeing a dietitian, doing a soup cleanse, P90X, and even getting a personal trainer. Nothing seemed to work for me.

BuzzFeedVideo

I love cooking healthy meals and I dance four to five times per week. I have always been frustrated with why it’s so hard for me to lose weight. I tried all sorts of methods to lose weight and get fit, including a raw vegan diet, Weight Watchers, seeing a dietitian, doing a soup cleanse, P90X, and even getting a personal trainer. Nothing seemed to work for me.

I started to believe that maybe it’s just my genetics.

Not ever seeing results discouraged me so much to the point that I wanted to just give up. It turned into a continuous cycle of embarking on a new diet or fitness plan, not seeing any real change after a few months, and then just giving up again.

BuzzFeedVideo

Not ever seeing results discouraged me so much to the point that I wanted to just give up. It turned into a continuous cycle of embarking on a new diet or fitness plan, not seeing any real change after a few months, and then just giving up again.

Then I found out about this thing called FitnessGenes and took a DNA test.

FitnessGenes is a genetic testing company that develops personalized fitness and nutrition plans based on an individual's DNA. I met with Dr. Dan Reardon, the CEO/cofounder, and took a DNA test. The results took one month to process. When I finally got them back, I was shocked.

BuzzFeedVideo

FitnessGenes is a genetic testing company that develops personalized fitness and nutrition plans based on an individual’s DNA. I met with Dr. Dan Reardon, the CEO/cofounder, and took a DNA test. The results took one month to process. When I finally got them back, I was shocked.

I sat down with Dr. Dan to learn more about my genetics and how my body works. Here’s what I learned:

1. My suspicion was correct. Genetically, I do have a slower metabolism. Dr. Dan described this in scientific terms as an "efficient metabolism," meaning that I store energy more than someone with a fast or "inefficient metabolism." 2. I also have a gene variation for the FTO gene that is linked to a hormone called ghrelin, which controls hunger. My gene variation implies that I am someone who becomes hungry very easily, therefore creating a higher risk of overeating. Dan said that eating small, frequent meals throughout the day to control hunger would be important. 3. I also have a gene variation in the APOA2 gene, indicating that I am sensitive to saturated fats, meaning that it sticks to me more easily! I asked Dr. Dan what foods have saturated fats and he said things like animal products, butter, dairy products, palm oil, and coconut oil. Coconut oil?! I ate so much coconut oil because of how often it's promoted as a healthy oil. No wonder I was having trouble.4. I am someone who would benefit from working out later in the day because my CLOCK gene variations imply that I am a night owl. This made perfect sense because I am definitely not a morning person.5. I am someone who responds well to "high-volume training," meaning high sets and reps of weight training. I always thought that lots of cardio would be the key to losing weight. It turns out that it was going to take a lot of strength training. Dan said that the more muscle I built, the more fat I would burn. 6. I am someone who does not switch from burning carbohydrates to burning fat easily. This would mean that I would need to be eating the right balance of macronutrients: carbs, protein and fat.7. Dan also said that I have a gene variation that indicates I metabolize caffeine slowly. This means that I would benefit by having a cup of green tea about 30 minutes prior to a workout for optimal energy.

BuzzFeedVideo

1. My suspicion was correct. Genetically, I do have a slower metabolism. Dr. Dan described this in scientific terms as an “efficient metabolism,” meaning that I store energy more than someone with a fast or “inefficient metabolism.”

2. I also have a gene variation for the FTO gene that is linked to a hormone called ghrelin, which controls hunger. My gene variation implies that I am someone who becomes hungry very easily, therefore creating a higher risk of overeating. Dan said that eating small, frequent meals throughout the day to control hunger would be important.

3. I also have a gene variation in the APOA2 gene, indicating that I am sensitive to saturated fats, meaning that it sticks to me more easily! I asked Dr. Dan what foods have saturated fats and he said things like animal products, butter, dairy products, palm oil, and coconut oil. Coconut oil?! I ate so much coconut oil because of how often it’s promoted as a healthy oil. No wonder I was having trouble.

4. I am someone who would benefit from working out later in the day because my CLOCK gene variations imply that I am a night owl. This made perfect sense because I am definitely not a morning person.

5. I am someone who responds well to “high-volume training,” meaning high sets and reps of weight training. I always thought that lots of cardio would be the key to losing weight. It turns out that it was going to take a lot of strength training. Dan said that the more muscle I built, the more fat I would burn.

6. I am someone who does not switch from burning carbohydrates to burning fat easily. This would mean that I would need to be eating the right balance of macronutrients: carbs, protein and fat.

7. Dan also said that I have a gene variation that indicates I metabolize caffeine slowly. This means that I would benefit by having a cup of green tea about 30 minutes prior to a workout for optimal energy.

Instead of counting calories, I tracked my macronutrients.

Dan said it would be important to have 1,700–1,900 calories maximum per day, since I am someone with a slow metabolism. However, instead of counting calories, which had put me in a negative headspace in the past, I tracked my macronutrients every day using this whiteboard. Macronutrient breakdown Carbohydrates: 40% Protein: 30% Fat: 30% (less than 8% coming from saturated fats, and the main source coming from monounsaturated fats. This would include foods such as almonds, olive oil, avocado, sesame oil, and canola oil.)

BuzzFeedVideo

Dan said it would be important to have 1,700–1,900 calories maximum per day, since I am someone with a slow metabolism. However, instead of counting calories, which had put me in a negative headspace in the past, I tracked my macronutrients every day using this whiteboard.

Macronutrient breakdown

Carbohydrates: 40%

Protein: 30%

Fat: 30% (less than 8% coming from saturated fats, and the main source coming from monounsaturated fats. This would include foods such as almonds, olive oil, avocado, sesame oil, and canola oil.)

I learned how to create meals that were delicious and healthy for my body.

The 30-day plan was easy to follow, but it did take a lot of hard work.

I worked out with Dan three to four times per week doing strength training and high-intensity interval training (HIIT). I had two active recovery days and also took a brisk walk every morning. Yes, there were times when I wanted to quit, but I felt stronger and stronger as the time went by. It motivated me even more to continue.

BuzzFeed Video

I worked out with Dan three to four times per week doing strength training and high-intensity interval training (HIIT). I had two active recovery days and also took a brisk walk every morning. Yes, there were times when I wanted to quit, but I felt stronger and stronger as the time went by. It motivated me even more to continue.

I couldn’t have done it without a strong support system.

I was lucky enough to have friends who were invested in me and seeing me succeed. They were even willing to work out with me!

After 30 days, I could not believe the results!

I didn't weigh myself the entire 30 days, because I didn't want to be discouraged by the numbers. Instead, I focused on how I was feeling. I had more energy than I have ever had before! In the end, it really wasn't about the numbers for me. I just wanted to be the healthiest, happiest version of myself.

BuzzFeedVideo

I didn’t weigh myself the entire 30 days, because I didn’t want to be discouraged by the numbers. Instead, I focused on how I was feeling. I had more energy than I have ever had before! In the end, it really wasn’t about the numbers for me. I just wanted to be the healthiest, happiest version of myself.

Although I lost weight and body fat, it was never about the numbers for me. I came out of this experience a different person on the inside, and that is what matters to me the most.

This experience allowed me to trust my body more than I ever have. I realized that I was always caught in this mindset that I was somehow "broken," and that nothing would ever work for me. In reality, I just needed to learn more about my body and how I function as an individual. We live in a culture where everyone is trying to tell you what's healthy, and this gave me the peace of mind to know what's actually healthy for my own body. This is only the beginning for me!

BuzzFeedVideo

This experience allowed me to trust my body more than I ever have. I realized that I was always caught in this mindset that I was somehow “broken,” and that nothing would ever work for me. In reality, I just needed to learn more about my body and how I function as an individual. We live in a culture where everyone is trying to tell you what’s healthy, and this gave me the peace of mind to know what’s actually healthy for my own body. This is only the beginning for me!

FitnessGenes is offering a 20% discount for BuzzFeed users using code BUZZFEED at checkout. Follow this link.

Special thanks to Granite Gym and Sanctuary Fitness LA for use of their facilities.

[“Source-buzzfeed”]

Weekly poll results: the Galaxy S8 is poised to outsell the Galaxy S8 Plus

The Galaxy S7 edge outsold its smaller sibling, the S7. Now leaked schematics show us that the next gen phones will have even bigger screen, will we see the Galaxy S8 Plus outsell the smaller Galaxy S8?

Our preliminary polling says no – if our math is right, the smaller S8 will put an S7 edge-size screen into an S7-size body. And it won 35% of votes, leading the S8 Plus (6.3” screen in an S7 edge body).

Of course, there are other considerations that might swing the results. The current consensus is that the Galaxy S8 Plus will have a dual camera, while the S8 will not. However, the Galaxy S8 will have stereo speakers while case designs for the Plus model show only one speaker grill.

It’s important to note that the S8 Plus wasn’t second in the polls, it was the hypothetical 5.1” Galaxy S8. Samsung hasn’t made a Galaxy S mini since the S5 generation (the Galaxy A phones took over), but can you imagine how compact a 5.1” S8 will be with these new super slim bezels?

Finally, 16% of voters say they will hold out for the Galaxy Note8 – if bigger is better then it’s clear that the Note8 will be the best, right?

source”cnbc”

UPSC CDS (I) 2016: Results declared at upsc.gov.in

The Union Public Service Commission (UPSC) has declared the result of the Combined Defence Service (CDS) Examination today on January 28. The marks of the candidates will be available within 15 days from the date of declaration of the final result on commission’s website for 60 days.

Result declared at upsc.gov.in

Result declared at upsc.gov.in

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The Union Public Service Commission (UPSC) has declared the result of the Combined Defence Service (CDS) Examination today, i.e. January 28. All those candidates who had appeared for the same are required to check their respective results at its official website, www.upsc.gov.in  . The new course will begin in April.

The website contains the lists, in order of merit, of 199 (153 men and 46 women) candidates who have finally qualified on the basis of the results of the CDS I (2016) and interviews held by the Services Selection Board of the Ministry of Defence for admission to the (i) Officers’ Training Academy, Chennai for 105th Short Service Commission Course (for Men); and (ii) 19th Short Service Commission Women (Non-Technical) Course, commencing in April, 2017.

(Read: Indian Bank PO Results 2017: Likely to be declared soon at indianbank.in)

Steps to check the result:

  • Log on to the official website, www.upsc.gov.in
  • Under ‘What’s New’, click on ‘Final result: CDS (I) 2016 (OTA)’
  • A PDF file will open containing the roll numbers and names of the selected candidates
  • Check your roll number
  • Download the same and take a print out for future reference.

The marks of the candidates will be available within 15 days from the date of declaration of the final result on the commission’s website for 60 days. Also, the result of medical examination has not been taken into account.

About UPSC:

UPSC conducts the Combined Defence Services (CDS) examination twice a year for the recruitment of candidates to the Indian Military Academy, Officers Training Academy, Indian Naval Academy and Indian Air Force Academy.

source”cnbc”

JKBOSE Class 12 exams 2016: Results of Jammu (winter zone) declared

As many as 58,293 students appeared in the examinations out of which 84.61 per cent boys and 81.45 per cent girls cleared the examinations successfully.

JKBOSE Class 12 results 2016 of Jammu (winter zone) declared

JKBOSE Class 12 results 2016 of Jammu (winter zone) declared

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The results of Higher Secondary (part two) 2016 (regular) of Jammu (Winter zone) have been declared. The candidates who had appeared for the examinations can check the results by logging on to the official website, jkbose.co.in  . 

As many as 58,293 students appeared in the examinations out of which 84.61 per cent boys and 81.45 per cent girls cleared the examinations successfully.

Steps to check the results:

  • Visit the official website, jkbose.co.in
  • Click on the relevant link
  • Enter the required details– registration number and roll number
  • Click on submit
  • Results will appear on the screen
  • Download it and take a print out for further reference.

About JKBOSE:

The Jammu and Kashmir State Board of School Education, the main board of school education in the Indian state of Jammu and Kashmir, is an autonomous body under the administration of the state government of Jammu and Kashmir. The board has more than 10,609 schools across the state affiliated under it and employs around 22,300 teachers.

The main aim of JKBOSE is to achieve excellence in the development and implementation of academic plans for students in the state of Jammu and Kashmir.

source”cnbc”

HC puts BSSC Junior Engineer Results 2016 on hold: Check full report here

The Bihar Staff Selection Commission (BSSC) Junior Engineer results have been put on hold by the Patna High Court.

HC puts BSSC Junior Engineer Results 2016 on hold: Check full report here

HC puts BSSC Junior Engineer Results 2016 on hold: Check full report here

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The Patna High Court has recently issued a court order regarding the Bihar Staff Selection Commission (BSSC) Junior Engineer results. As per reports, the court has put Junior Engineer results on hold.

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Reasons for passing this order:

  • This decision from the government came in after a Public Interest Litigation (PIL) was filed by Rajiv Ranjan Kumar and others against the irregularities reported during the conduct of the written exam
  • Advocate Deenu Kumar, appearing on the behalf of petitioners in a recent report, said, “During the first shift exam at SB College, Maulabagh, Arrah, the candidates were given second shift paper, to which the candidates protested. Patrolling Magistrate reported the matter to Nawada Thana and filed a FIR against the ten people including the center superintendent.”
  • Furthermore, advocate said that from a long time now, irregularities in the examination process is seen while the Staff Selection Commission has been busy in publishing the results

To this, the bench of Justice Ajay Kumar Tripathi has ordered the state government to submit the response within four weeks time.

As per reports, the written examination was conducted for filling Junior Engineer posts in Water Resources Department on September 25, 2016.


Details of posts offered:

Total posts: 2,030

Name of the post:

Junior Engineer (Civil): 1,988

Junior Engineer (Mechanical): 42

Once the case gets solved, results of the same will be declared by the commission.

Steps to check the results:

  • Log on to the official website, http://bssc.bih.nic.in/
  • Click on the relevant link
  • Enter all the required information in space provided
  • Click to submit
  • Results will be displayed
  • Candidates are advised to take printout of the same for future reference

For more updates, all the candidates are advised to keep a constant check on the official website.

source”cnbc”

IBPS CWE PO Prelims Results 2016: Declared at ibps.in

The Institute of Banking Personnel (IBPS) has published the results of the  preliminary examination of Probationary Officers(PO)/Management Trainee (MT) at ibps.in

IBPS CWE PO Prelims Results 2016

IBPS CWE PO Prelims Results 2016

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The Institute of Banking Personnel (IBPS) has published the results of the preliminary examination of Probationary Officers(PO)/Management Trainee (MT) on its official website, ibps.in

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How to check the results?

  • Go to the official website
  • Click on the link, ‘Click here to view your preliminary exam result status for CWE PO-MT – VI’
  • Enter registration number/roll number and password
  • After submitting the same, the results will be displayed on the screen
  • Take a printout for future reference

The preliminary examination was held on October 16, 22, 23 and October 27. The candidates who have qualified in the preliminary examination will have to appear for the main examination on November 20.  The admit cards for the mains examination will get released soon on the website. To know how to download, click here

The main examination will comprise 200 questions based on reasoning, english language, quantitative aptitude, general awareness (with special reference to banking) and computer knowledge. It will carry a total of 200 marks and will be held for a duration of 2 hours and 20 minutes.

source”cnbc”

DAVV,UG,Exams,2016:,Semester,results,to,be,declared,in,November,at,dauniv.ac.in

DAVV UG Exams 2016: Semester IV results to be declared in November at dauniv.ac.in

Devi Ahilya Vishwavidyalaya has released an official notification regarding release of semester I and V UG examination results.

Recently, the controller of examinations at the varsity Ashesh Tiwari has said that the results of the same will be released by next week on the official website, the link for which is www. dauniv.ac.in

How to check the results?

In order to check the results, all the candidates need to follow the below mentioned steps:

  • Log on to the official website
  • Click on relevant link
  • Enter all the required details such as roll number and date of birth in the space provided
  • Results will be displayed
  • Take a printout for future reference

As per recent report of The Free Press Journal, the varsity will release the results of the semester II exams in November.

As per sources, the results of semesters II and IV exams have been delayed as the examination was conducted four to five months back.
According to Tiwari, the evaluation of the results has not been completed on time.

Tiwari said that college principals withheld the answer sheets for almost two months and sent them back unchecked, reasoning that there was no one to check the papers.

About university:

Devi Ahilya Vishwavidyalaya formerly the University of Indore was established in 1964 by an Act of Legislature of Madhya Pradesh. His Excellency Dr. Zakir Hussain, then Vice President of India, inaugurated the university in 1964.

Later on, its jurisdiction was extended to seven tribal dominated districts of Indore division namely, Jhabua,  Alirajpur, Dhar, Khargone, Khandwa, Burhanpur and Barwan

source”cnbc”

UPSC CAPF (ACs) 2016: Results declared at upsc.gov.in

UPSC CAPF (ACs) 2016

The result of Central Armed Police Forces (CAPF) (Assistant Commandants) written examination has been declared by the Union Public Service Commission (UPSC). All those candidates who have appeared for the same may check their respective result at the official websitewww.upsc.gov.in

The examination was conducted on June 26. All those candidates who have qualified this exam are now eligible to appear for the physical standards test/physical efficiency test and medical standards test.

The marksheets and other related information will be put on the website within 15 days from the date of publication of the final result (after conducting personality test) and shall remain available there for a period of 30 days.

Steps to check the result:

  • Log on to the official website www.upsc.gov.in
  • Click on ‘Written result – CAPF 2016’
  • A pdf file will open which will contain all the roll numbers of the selected candidates
  • Download the same and take a print out for future reference

(Read: JCSIR UGC NET to be held on Dec 18: Check out paper pattern, other details)

The candidates will be required to produce the original certificates in support of their claims pertaining to age, educational qualifications, community etc. at the time of the personality test. The Border Security Force (BSF) will intimate the candidates about the date, time and venue of the physical standards test/physical efficiency test (PET) and medical standards test to be conducted by them.

Next step:

The qualified candidates are required to fill up detailed application form (DAF) online along with uploading of the scanned copies of relevant certificates/documents in support of their eligibility, claim of reservation etc. through the commission’s website.

A hard copy of the on-line filled detailed application form, along with relevant documents like proof of date of birth, educational qualification, caste, civilian central govt. service employee, resident of J&K etc. is to be submitted by the candidates to the BSF authorities at the time of conduct of their PST/PET/MST.

source”gsmarena”

CBSE Class 12 Compartment 2016: Results declared at cbseresults.nic.in:

CBSE Class 12 Compartment Result 2016 declared at cbseresults.nic.in

The Central Board of Secondary Education (CBSE) has declared the results of the class 12 compartmental examination on the official website, the link for which is cbseresults.nic.in .

The Board has conducted the examination on July 16.

The practical examination was held within three days after the theory examination was over.

The board conducted the examination on July 16 at various centres.

 

As per reports, the practical examination was held within three days after the theory examination was over.

How to check the results?

In order to check the results, all the candidates need to follow the below mentioned steps:

  •  Log on to the official website, cbse.nic.in
  • Click on the ‘Exam results’ section
  • The result page will be displayed
  • Click on the link ‘Compartment Result-2016 for Class-XII’
  • Enter all the required details such as roll number and school number
  • The result will be displayed

All the candidates are advised to take printout of the same for future reference

Meanwhile, the CBSE declared the results of Class 12 board examination on May 21 around 10 am on the official website.

As per reports, a total of 14,99,122 candidates have applied, out of which 44,66,41 are girls and 6,21,259 are boys.

This year, Sukriti Gupta from Montfort School in Ashok Vihar has topped CBSE by scoring 497 marks out of 500.

According to earlier reports, the CBSE results were going to be released by August 20 but the Board has released the Class 12 compartment result a little early this year.


About the board:

The Central Board of Secondary Education (CBSE) was founded on November 3, 1962. It’s headquartered at Preet Vihar, New Delhi. CBSE regulates and supervises the development of education in the country. Its primary function includes preparing academic programmes and organising examinations, especially for Class 10 and Class 12 students.

For any query, the candidates can visit the official website, the link for which is cbse.nic.in

India Today Education wishes students good luck for their future endeavors.

[“source -cncb”]