Vitamin D May Ease Sunburns by Reducing Skin Damage

Image result for Vitamin D May Ease Sunburns by Reducing Skin DamageA high dosage of vitamin D after your next sunburn could mean the difference between weeks of agony and a quick recovery.

After exposing 20 participants to a small UV lamp sunburn on the inside of their arms, researchers from Case Western Reserve University in Ohio analyzed how vitamin D helped reduce inflammation. Kurt Lu, senior author and professor of Dermatology at the university and University Hospitals Cleveland Medical Center, said the results depended on the dose each participant was given.

Credit: Phil Kates/Flickr, CC BY-SA 2.0

“We found benefits from vitamin D were dose-dependent,” Lu said in a press release. “We hypothesize that vitamin D helps promote protective barriers in the skin by rapidly reducing inflammation. What we did not expect was that at a certain dose, vitamin D not only was capable of suppressing inflammation, it was also activating skin repair genes.”

The participants were given either a placebo pill or 50,000, 100,000 or 200,000 IU of vitamin D an hour after exposure to the UV lamp. Researchers checked in with the participants up to a week after the experiment and collected skin biopsies for further testing.

Related: Vitamin D Deficiency May Cause Early Menopause

“The diverse immunomodulatory effects of vitamin D are increasingly being recognized. However, the ability of oral vitamin D to modulate acute inflammation has not been recognized,” the researchers said.

Those who received the largest dose of vitamin D experienced reduced skin inflammation, less epidermal structural damage and reduced expression of pro-inflammatory markers within the skin two days after being exposed to the UV lamp. Participants who had the highest blood levels of vitamin D experienced reduced skin redness and increased gene activity associated with skin cell repair.

“The data may have broad implications for immunotherapeutic properties of vitamin D in skin homeostasis and implicate … regulation as a previously unreported mechanism by which vitamin D exerts anti-inflammatory effects in humans,” the researchers said.

Related: Scientists Create Topical Drug That Tans Skin

The participants were separated into two clusters based on similarities in their gene expression profiles and differed significantly in their vitamin D levels after treatment. Every individual’s response to vitamin D depended on his/her age, BMI, baseline vitamin D stores and genetic variations.

The researchers suggested that vitamin D has other additional benefits, such as reducing DNA damage. Since vitamin D is relatively cost-effective, the treatment could be used in the near future as an easy fix to sun-related skin damage.

“The simplicity and safety of high dose oral vitamin D treatment, combined with its rapid and sustained therapeutic efficacy, suggest that these proof-of-concept findings may ultimately be translated to routine clinical use once larger studies are performed on diverse populations of subjects,” the researchers said.


Low Vit. D level and risk of bladder cancer are interlinked

Low Vit. D level and risk of bladder cancer are interlinkedLow Vit. D level and risk of bladder cancer are interlinked
A systematic review of seven studies say that lack of Vitamin D in human body is associated with an increased risk of developing bladder cancer.
Though further clinical studies are needed to confirm the findings, the study adds to a growing body of evidence on the importance of maintaining adequate Vitamin D levels.

Vitamin D, which is produced by the body through exposure to sunshine, helps the body control calcium and phosphate levels. Vitamin D can also be obtained from food sources such as fatty fish and egg yolks. Previous studies have linked vitamin D deficiency with a host of health problems including cardiovascular disease, cognitive impairment, autoimmune conditions, and cancer.

In countries with low levels of sunlight, it is difficult to obtain enough vitamin D from food alone. In the UK, one in five adults is vitamin D deficient and three in five have low levels. This is especially prevalent in people with darker skin: in winter, 75 percent of dark-skinned people in the UK are vitamin D deficient.

In this work, researchers from the University of Warwick and University Hospital Coventry and Warwickshire, Coventry and the investigated the link between vitamin D and bladder cancer risk. They reviewed seven studies on the topic which ranged from having 112 to 1125 participants each. Five out of the seven studies linked low vitamin D levels to an increased risk of bladder cancer.


Mini One D Clubman launched in the UK

Mini One D Clubman launched in the UK

The Mini One D Clubman has been launched in the UK.  This is the new entry-level model from Mini and can be had in both manual and automatic guises. Prices start at 21,375 GBP (Rs 20.59 lakh) for the manual and 22,870 (Rs 22.04 lakh) for the automatic variant.

The One D Clubman is powered by a 1.5-litre three-cylinder diesel engine that produces 116bhp and 270Nm of torque. 0-100kmph comes up in a respectable 10.4 seconds while the top-speed is 191kmph. The manual is a six-speed box while the automatic is a six-speed steptronic.

This One D Clubman gets quite a lot of features despite being an entry-level model.  This list includes automatic headlamps and wipers, fog lamps, cruise control, 16-inch alloy wheels, TPMS, satellite navigation and floor mats.

Those interested can also go for the Chili pack which gets leather seats, park assist, climate control and LED lights. On the safety front, this One D Clubman gets six airbags and seatbelt pre-tensioners.

During the 2016 Auto Expo, BMW had announced that the new Clubman would be coming to India and it is expected to be this model. It will be priced higher than the regular Mini range and will be locally assembled at BMW’s plant outside Chennai.
[“source -pcworld”]