Vitamin D May Ease Sunburns by Reducing Skin Damage

Image result for Vitamin D May Ease Sunburns by Reducing Skin DamageA high dosage of vitamin D after your next sunburn could mean the difference between weeks of agony and a quick recovery.

After exposing 20 participants to a small UV lamp sunburn on the inside of their arms, researchers from Case Western Reserve University in Ohio analyzed how vitamin D helped reduce inflammation. Kurt Lu, senior author and professor of Dermatology at the university and University Hospitals Cleveland Medical Center, said the results depended on the dose each participant was given.

Credit: Phil Kates/Flickr, CC BY-SA 2.0

“We found benefits from vitamin D were dose-dependent,” Lu said in a press release. “We hypothesize that vitamin D helps promote protective barriers in the skin by rapidly reducing inflammation. What we did not expect was that at a certain dose, vitamin D not only was capable of suppressing inflammation, it was also activating skin repair genes.”

The participants were given either a placebo pill or 50,000, 100,000 or 200,000 IU of vitamin D an hour after exposure to the UV lamp. Researchers checked in with the participants up to a week after the experiment and collected skin biopsies for further testing.

Related: Vitamin D Deficiency May Cause Early Menopause

“The diverse immunomodulatory effects of vitamin D are increasingly being recognized. However, the ability of oral vitamin D to modulate acute inflammation has not been recognized,” the researchers said.

Those who received the largest dose of vitamin D experienced reduced skin inflammation, less epidermal structural damage and reduced expression of pro-inflammatory markers within the skin two days after being exposed to the UV lamp. Participants who had the highest blood levels of vitamin D experienced reduced skin redness and increased gene activity associated with skin cell repair.

“The data may have broad implications for immunotherapeutic properties of vitamin D in skin homeostasis and implicate … regulation as a previously unreported mechanism by which vitamin D exerts anti-inflammatory effects in humans,” the researchers said.

Related: Scientists Create Topical Drug That Tans Skin

The participants were separated into two clusters based on similarities in their gene expression profiles and differed significantly in their vitamin D levels after treatment. Every individual’s response to vitamin D depended on his/her age, BMI, baseline vitamin D stores and genetic variations.

The researchers suggested that vitamin D has other additional benefits, such as reducing DNA damage. Since vitamin D is relatively cost-effective, the treatment could be used in the near future as an easy fix to sun-related skin damage.

“The simplicity and safety of high dose oral vitamin D treatment, combined with its rapid and sustained therapeutic efficacy, suggest that these proof-of-concept findings may ultimately be translated to routine clinical use once larger studies are performed on diverse populations of subjects,” the researchers said.

[“Source-vitalupdates”]

Post-Brexit EU drug regulation deal urged by ministers

Laboratory

The UK will continue to co-operate with the European Union on medicine testing after it leaves the bloc, two senior ministers have suggested.

Business Secretary Greg Clark and Health Secretary Jeremy Hunt said such a deal would be “in the interests of public health and safety”.

“The UK would like to find a way to continue to collaborate with the EU,” they wrote in a Financial Times letter.

There are fears Brexit may cause delays in UK patients getting new drugs.

Currently the London-based European Medicines Agency (EMA) authorises drugs for use across the EU, including the UK.

However, it is expected to move out of the UK after Brexit, raising uncertainty over whether the UK will need to develop its own separate drug approval system.

Industry experts have warned that if this happens pharmaceutical firms could be slower to seek permission for their drugs to be used in just one country, focusing instead on getting their drugs approved for larger, more lucrative markets.

The UK pharmaceuticals trade association has also warned that Brexit could undermine future investment, research and jobs in the country.

But speaking on the BBC’s Today programme, the UK managing director of US drugs giant Pfizer, Erik Nordkamp, said there were other issues than Brexit that the industry wanted to see addressed.

“The letter in the FT this morning is significant… because it acknowledges there are some risks that need to be addressed with regulation, with trade, but at the same time the government needs to address the long-standing issues that are there.”

Access to medicines

The ministers wrote that the UK “will look to continue to work closely with the European Medicines Agency (EMA).”

“Our overall aim is to ensure that patients in the UK and across the EU continue to be able to access the best and most innovative medicines,” they added.

In the letter, they cited examples where the UK and EU partnership had helped patients, including the licensing of 130 products to treat rare diseases.

In an attempt to reassure the industry, they also said if it wasn’t possible to arrange “our desired relationship with the EU”, then Britain would “set up a regulatory system” to process drugs licences “as quickly as possible.”

Greg ClarkImage copyrightPA
Image captionGreg Clark said the current UK and EU partnership had been beneficial

In April, EMA executive director Guido Rasi said continued co-operation was theoretically possible but it would be up to EU governments to decide whether to offer such a deal.

Pharmaceutical firms have been pushing for some kind of clarity over what the UK’s exit from the EU will mean for the industry.

Mike Thompson, chief executive of the Association of the British Pharmaceutical Industry, said the ministers’ letter was “a welcome recognition that the future of medicines regulation is a key priority for the government”.

[“Source-bbc”]

5 tips by PM Modi for students preparing for Classes 10 and 12 Board exams

To encourage the student in battling anxiety just a few months ahead of exams, PM Modi extended moral support by saying that students should find pleasure in exam by contemplating it as fun activities.

Narendra Modi

Narendra Modi

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Prime Minister Narendra Modi, in his first 2017 ‘Mann ki Baat’ session, captivates million of students across the country by rendering five erudite tips on how to face exams with a composed mind.

His speech was primarily dedicated for the students of Classes 10 and 12 who will be appearing for board examination in the coming days.

To encourage the student in battling anxiety over exams, PM gave a moral support by saying that students should find pleasure in exam by contemplating it as fun activities.

Wishing the best for the students, he concluded his ‘Mann ki Baat’ session.

Following are the five erudite tips from our own Prime Minister:

1.    Relax and don’t be panic over exam: “Smile more and score more” said the PM and added that students should be relaxed and not panic over exams. “Instead of chasing after marks, you should strive to gain knowledge,” he said adding, “Marks will follow if your mission and ambition are in sync.”

2.    Academic excellence alone cannot define success: focusing on lifelong development, he said that exams are not to be feared of as it is not the benchmark of success. Exams are not the test of a lifetime but a test of a year and urged the students not to compete with others but to compete with themselves.

3.    Lively environment: There should be a festive and lively environment in the house. Happiness in the house plays a pivotal role in student’s mental capabilities which are directly proportionate to educational performance as well. He also urged the parent to accept their wards of what they are and the way they are.

4.    Warned the students of unfair means: Emphasising on the moral fiber, he urged the students not to be tempted by the thought of securing marks by practicing unfair means. He said that instead of spending time on preparing to cheat during the exams, they should rather invest that time on studies. “If they cheat, what will they teach their children?” he asked.

5.    Proper rest: Like any other subject experts should have prescribed, Prime Minister Modi also recommends proper rest and to ensure adequate sleeps. While he also urged the students to stay physically fit, he also pointed out that there should be breaks during study hours.

source”cnbc”

IIM Bill 2017: Approved by cabinet, students will now get degrees instead of diplomas

The Bill enables the IIMs to award degrees instead of diplomas.

In picture, IIM-Calcutta (File Photo)

In picture, IIM-Calcutta (File Photo)

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The Union Cabinet on Tuesday approved the Indian Institute of Management Bill, 2017, granting them complete autonomy. Under the Bill, the IIMs would be declared as institutions of national importance and provided statutory powers.

After getting an approval from the law ministry, the human resource development (HRD) ministry may place the proposed draft of the Bill in the upcoming budget session of the parliament.

Till now, only 20 premier institutes give post graduate diplomas to the students.

The Bill enables the IIMs to award degrees instead of diplomas.

HRD minister Prakash Javadekar tweeted:

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Prakash Javadekar

@PrakashJavdekar

Historic decision to give IIMs real autonomy&grant degrees.We trust excellence&quality.This reflects vision of ModiGovt for higher education

  • 169169 Retweets

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As per the sources, the Bill will grant powers to the board of governors to order a probe against an IIM director, if his institute fails to perform as per the proposed Act. A person similar to the rank of a High Court judge will conduct the investigation.

According to the proposed draft, the board must evaluate the performance of the new institute within the first three years of its set up and continue to check on a period of short intervals.

source”cnbc”

Jamia Millia Islamia centenary celebrations: Special postal cover to be issued by the postal department

The special cover with a picture of the university that was founded in 1920 will be released today at the District Level Philately Exhibition- “Kalindi 2017” at Jamia

In picture, Jamia Millia Islamia University (File photo)

In picture, Jamia Millia Islamia University (File photo)

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To mark the centenary celebrations of Jamia Millia Islamia, the Postal Department will issue a special cover featuring the picture of the university, that has contributed in the field of education over the years.

The special cover with a picture of the university that was founded in 1920 will be released today, i.e.Thursday, at the District Level Philately Exhibition- “Kalindi 2017” at Jamia which is being organised by the Ministry of Communications and will be presided over by L.N. Sharma, Chief Postmaster General of Delhi Circle.

Report in details:

“The objective of the exhibition is to showcase to the general public, in particular, the youth, the cultural and educational aspects of the hobby of stamp collection and to facilitate expansion of friendly-relations and cooperation among postal staff, philatelists, philatelic dealers and the media,” an official statement said.

The special cover on the Jamia Millia priced at Rs 10 along with other old stamps will be on display and sale during the exhibition.

The objective of the exhibition is to showcase to the general public, in particular the youths, the cultural and educational aspects of the hobby of stamp collection.

source”cnbc”

Quiz: Know if you are stressed by taking this color quiz

TNN | December 02, 2016
Are you stressed? Find out!

1/8Are you stressed? Find out!
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“Your attitude is like a box of crayons that colors your world. Constantly color your picture gray, and your picture will always be bleak. Try adding some bright colors to the picture by including humor, and your picture begins to lighten up.,” said Allen Klein. The colors that you perceive around you reflect on you in a certain way. Take up the following quiz and know if you are stressed, melancholic, or relaxed and happy.
(Picture courtesy: Vinoth Chandar/Flickr)

…READ MORE

Which color speaks to you the most?

2/8Which color speaks to you the most?
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A. Pink B. Green C. Red D. Yellow E. White F. Deep Red G. Black
Which color speaks to you the most?

3/8Which color speaks to you the most?
0
A. Blue B. Yellow C. Navy Blue D. Violet E. Pink F. Red G. Dark Green
(Picture courtesy: Sonya Bobb/Flickr)
Which color speaks to you the most?

4/8Which color speaks to you the most?
0
A. Yellow B. Pink C. Red D. Green E. Blue F. Dark Violet G. Shades of Grey
Which color speaks to you the most?

5/8Which color speaks to you the most?
0
A. White B. Peach C. Orange D. Yellow E. Blue F. Red G. Black
(Picture courtesy: Faith Goble/Flickr)
Which color speaks to you the most?

6/8Which color speaks to you the most?
0
A. Light Pink B. Mustard C. Yellow D. Hot Pink E. Rosewood Pink F. Black G. Flaxen
Which color speaks to you the most?

7/8Which color speaks to you the most?
0
A. Blue B. White C. Orange D. Shades of Green E. Brown F. Red G. Black
Find out here!

8/8Find out here!
0
Disclaimer: This should not be considered as a substitute for Physician’s advice. Please consult your treating Physician for more details.
source”cnbc”

World warmer by 1.2 degrees, 2016 warmest year ever: WMO

IANS | Updated: Nov 15, 2016, 12.06 PM IST

World warmer by 1.2 degrees, 2016 warmest year ever: WMO (Maisie Paterson/Getty Images)World warmer by 1.2 degrees, 2016 warmest year ever: WMO (Maisie Paterson/Getty Images)
The World Metrological Organisation (WMO) on Monday said the global temperature is 1.2 degrees Celsius above the pre-industrial level and will set a new high for the third year running.

It also said 2016 is the hottest year on record, 2015 the second hottest and 2014 in the third place.

“Another year. Another record,” said WMO Secretary General Petteri Taalas while releasing the report at the Marrakech climate change negotiations at COP22.

He said the extra heat from powerful El Nino phenomenon has disappeared. The heat from global warming will continue.

The WMO on November 8 informed the parties and non-parties at the enviromental meet that while 2015 was the warmest year so far, 2016 is on track of being even warmer. On Monday, it confirmed its prediction.

The WMO said these alarming trends have resulted in ten-fold increase in “extreme events” globally, that is, catastrophic events such as cyclones, heatwaves, floods and droughts have become frequent in 10-year cycle rather than 100-year cycle.

The WMO report came as a major challenge ahead of the major goal of the landmark Paris Climate Change Agreement (COP21), that aims at keeping the global temperature rise this century well below 2 degrees Celsius above pre-industrial level and to pursue efforts to limit the temperature increase even further to 1.5 degrees.

“On the day the WMO confirmed that 2016 is set to be the hottest year on record, it is shocking the world has been largely silent on one of the biggest-ever global climate emergencies. This year, over 400 million people were affected by the strongest ever ‘El Nino’ weather event, causing droughts around the world,” ActionAid climate change policy expert Teresa Anderson said in response to the report.

Anderson said the impacts of El Nino confirm the need for the world to take urgent action on climate change, which affects women and children the worst.

ActionAid said inspite of the huge drought, the world has remained largely silent on the crisis.

It said countries and humanitarian agencies face a funding gap of $3.1 billion to meet the needs of those still affected.

“The governments that promised climate compassion in Paris have apparently turned their back on an actual global climate crisis,” Anderson added.

The El Nino weather phenomenon helped push temperatures even higher in early 2016 but the global warming caused by the greenhouse gas emissions from human activities remains the strongest factor.

According to the 2015 Greenhouse Gas Bulletin, approximately 44 per cent of the total carbon dioxide (CO2) emitted by human activity from 2004 to 2015 remained in the atmosphere, with the remaining 56

source”cnbc”

OnePlus 3 Android Nougat beta update out this month, final release hits by the end of the year

Yesterday ZTE finally told us when to expect an Android 7.0 Nougat update to hit its Axon 7smartphone, and today it’s time for OnePlus to come clean regarding its latest flagship, the OnePlus 3. A beta build of Nougat for the handset will become available this month, apparently, with the final release being rolled out by the end of the year.

That means OnePlus will beat ZTE at the update game, since the Axon 7 is only tasting Nougat in January. OnePlus has confirmed that its flagship offering from last year, the OnePlus 2, is also in line to receive a Nougat update at some point. However, exactly when that will happen isn’t known yet. We assume there’s no way for that to arrive before 2017, though.

As for the OnePlus X and OnePlus One, those aren’t going to see official Nougat builds because of their chipset, which can’t support certain graphics-related requirements in Android 7.0. OnePlus is expected to launch a new phone next week – this will be dubbed OnePlus 3Tand should be sold running Nougat from day one.

Source

source”cnbc”

Dishonored 2’s buggy PC port is plagued by performance problems

I guess this launch won’t be as smooth as Doom.

dishonored 2
6COMMENTS
Update, November 11: With Dishonored 2‘s Steam rating down to 54 percent, Bethesda’s finally got around to acknowledging there maaaay be some issues, and a patch is on its way soon.

From the official update:

“We have been monitoring the PC forums and social channels and while we’re excited to hear that many of you are enjoying the game, we are disheartened that some of you are experiencing PC performance issues on some systems. We are actively working to provide an update to address your concerns. The patch and its release notes will be available in the coming days.”

Original story: Despite Dishonored 2’s official release date being November 11, it’s basically out now—at least if you preordered. Those who did already have access to the game, which means…well, the release date is just November 10? Right?

In any case, performance numbers have started flowing in. Dishonored 2 ($60 on Steam) is running pretty well on my rig, which sports an i7-5820K and a GeForce GTX 980 Ti. On Very High settings at 1920×1080 I average around 90 frames per second, with it dipping to 70 in busy areas. Ultra drops that to 80-ish with dips to around 65 at times. Still playable, though I’ll probably stick to Very High.

But PC Gamer and the greater Steam community are seeing quite a few problems on mid-tier and lower-end PCs. As of writing, the game’s sitting at a 65 percent rating on Steam, with many users trotting out the age-old phrases of damnation: “Poorly optimized,” “Performance issues,” and “Terrible PC port.”

deus ex 1

That 20 frame dip I mentioned above when entering busy areas? People are seeing that across the board, and if you’re barely hitting 60fps already it brings the game crashing down to around 40fps or even lower. And don’t think these people are playing on potato PCs. I’ve seen reports as low as 20 to 40 frames per second on a GTX 970…at medium settings. I can assure you, the game doesn’t look good enough to justify performance that poor.

PC Gamer and numerous Steam reviews also mention that the game starts having refresh rate issues at lower frame rates, with PC Gamer noting that as a result “even 45 fps can feel nauseating.”

dishonored 3

And then there are issues I can corroborate myself. Even with Dynamic Resolution set to 100 percent the game looks blurrier than I’d expect, as if it’s being upscaled. The mouse is a mess. My sensitivity (and again, this is mentioned in Steam reviews too) seems to fluctuate all on its own, with it sometimes slow and cumbersome to turn and other times whip-fast, without me adjusting anything. I find myself constantly adjusting my G502’s DPI on-the-fly as I’m playing to keep it somewhat constant.

Also—and this doesn’t has no effect on gameplay but rams home the “bad port” feel—on loading screens the mouse stutters and jumps around as it’s moved, even once the level is fully loaded. And the jumpiness isn’t limited to the visuals, as PC Gamer reports running into audio stuttering on several of its test rigs.

As I said, it’s playable enough on my system. I’ll probably be churning through it over the weekend, trying to wrap my head around the story and do a real review some justice. (So far it seems fun.) But issues are widespread enough it’s worth saying: Maybe hold off before buying yourself a PC copy of Dishonored 2. Give it a few patches.

source”cnbc”

Android 7.0 ‘Galaxy Beta Program’ officially announced by Samsung

Samsung has officially announced Android 7.0 ‘Galaxy Beta Program’ for users of the company’s Galaxy S7 and S7 edge smartphones.

While we know that the program is already live in South Korea, the announcement says the Galaxy Beta Program is now open to users in the US and UK as well. Users in China will also be able to participate soon.

“Applicants are currently being accepted on a first-come, first-served basis,” the company says. “Throughout the Galaxy Beta Program period, users can get a feel for Android 7.0 Nougat with Samsung’s latest UX, and can provide feedback on performance, reliability and usability.”

It’s worth mentioning that Galaxy S7 edge Olympic Games Limited Edition as well as Galaxy S7 edge Injustice Edition aren’t included in the program. Also, for the U.K, the program is only available to those who have a non-operator locked device or purchased an open market version.

For more details, including how to apply for the program, head to the Source link below

source”cnbc”