Puma Biotech Jumps On Breast Cancer Drug Approval

Leerink’s Michael Schmidt and Varun Kumarreiterated an Outperform rating on the stock today, writing that while the approval isn’t a surprise, it has removed an overhang for the stock, and it came in earlier than expected to boot.

More detail from their note:

The product label looks broad, not restricting use to specific patient populations (e.g., hormone-receptor [HR] positive patients) and there is no black box warning. The prescribing information contains fairly detailed information about the use of antidiarrheal prophylaxis measures, providing specific information on how to manage the drug’s main side effect. Information on pricing and launch timing is not available yet; PBYI previously guided to a cost of therapy that is similar to that of other breast cancer drugs. We’d expect a US launch not immediately given that PBYI has hired a US sales force only contingent on obtaining regulatory approval. A recommendation from the European CHMP is still pending and expected later this month or next. We currently model $1.3Bn US Nerlynx peak sales in the extended adjuvant treatment setting based on relatively conservative assumptions and believe 2018E Street consensus of $215M should be achievable.

[Source:-.barrons]

Late announcer’s blog praised for drawing attention to breast cancer

Mao Kobayashi, who died of breast cancer on Thursday, is shown in a photo she posted soon after she began blogging. | KYODO

Following the death Thursday of popular TV presenter Mao Kobayashi from breast cancer, patient groups praised the blog she started to chronicle her battle with the disease, saying it helped raise public awareness of it.

Kobayashi used the blog to describe her family and daily life in detail.

Ikuko Nakazawa, a 65-year-old caretaker with a group of cancer patients in Tokyo’s Koto Ward, praised Kobayashi’s efforts.

“I think the blog showed the importance of staying together with a family,” Nakazawa said.

Since Kobayashi’s husband, kabuki actor Ichikawa Ebizo, announced last year that she was being treated for progressive breast cancer, a different group of cancer patients in Tokyo’s Meguro Ward has been receiving many messages and inquiries about the disease.

The blog has triggered interest and raised awareness, said a 64-year-old staff member from the group.

“Some patients may be disappointed by Mao’s death, but I want them to know there are many patients who overcome the disease,” said the staff member, who was treated for breast cancer 13 years ago. “I want young people to check themselves every month for lumps in their breasts, as well as get routine checkups.”

Eiko Yamaguchi, a 37-year-old Tokyo resident who is also a mother, agreed, saying Kobayashi triggered women to become more aware of their health.

Since Kobayashi came out with her story, Yamaguchi said she herself became more conscious about her health and believes “many women, motivated by the blog, went for health checkups.”

Three months after Ebizo announced his wife was battling cancer, Kobayashi started blogging about it. Her positive, future-oriented attitude to life with cancer attracted more than 2.5 million registered readers.

In her first post, she wrote that, thanks to her doctor’s advice “not to hide behind cancer,” she realized how her identity as a patient had dominated her mind and life and led her more and more toward the shadows.

“I have decided to say goodbye to the me who has been hiding behind cancer by using this blog as a tool, because I want to become a woman who lives her life vigorously and also be a strong mother for my children,” she wrote.

On the blog, she described her feelings when she was diagnosed with breast cancer, and when she lost her hair due to the side effects of chemotherapy. While reporting on her daily life with her family, she also acknowledged her worsening health, at one point saying the cancer had metastasized.

She sometimes posted photos of herself with a worn out but smiling face.

“I always pray to God, ‘Please give me a chance to support actor Ichikawa Ebizo as his partner,’” Kobayashi said when she appeared on a TV program featuring her husband that aired in January.

On Friday, the BBC, which had previously added Kobayashi to a list of influential women, reported that her blog was “groundbreaking in a country where people do not like to discuss personal issues.”

In November, the network picked Kobayashi as one of the 100 “most influential and inspirational women” in the world, noting that her blog, launched in September the same year, was “inspiring not only those who are also fighting cancer but many others.” Kobayashi was the first Japanese to make the annual list.

In a story contributed to the BBC at the time, Kobayashi said: “My life has been rich and colorful — I’ve achieved dreams, sometimes clawed my way through, and I met the love of my life. I’ve been blessed with two precious children. My family has loved me, and I’ve loved them. So I’ve decided not to allow the time I’ve been given to be overshadowed entirely by disease. I will be who I want to be.”

On Saturday morning, Ebizo posted a blog post saying, “From now on, I will be a dad and a mom.”

He added: “I will do the things Mao would have wanted to do and the life she would have wanted to live.”

 

 

 

[“source-japantimes”]

Nearly 1/2 of breast cancer patients have severe treatment side effects, 1 in 20 Indians suffers from depression

Health weekly roundupHealth weekly roundup
This week was packed with some very shocking yet important health news. To ensure that you don’t miss any, we bring you a weekly roundup. Here is this week’s aggregation of the latest news stories on health, fitness and diet.

Insomnia may triple the risk of asthma: Study

Asthma affects approximately 300 million people worldwide, with major risk factors including smoking, obesity and air pollution.

Mother’s cervical bacteria may help prevent premature birth

The presence of bacteria in a woman’s vagina and cervix may either increase the risk of premature birth or have a protective effect against it, researchers say.

Attention parents! Cooking in those aluminium pans may reduce your kid’s IQ

The findings published in journal Science of the Total Environment, indicate that cadmium is neurotoxic in children and causes kidney damage which is linked to cardiovascular deaths and is carcinogenic.

Eating celery, broccoli can improve treatment of breast cancer

The findings indicate that Luteolin, a naturally occurring, non-toxic plant compound that has been proven effective against several types of cancer.

‘Anxiety, depression may up risk of death from cancers’

Higher levels of anxiety and depression may increase the risk of death from certain cancers, scientists have warned.

Nearly half of breast cancer patients have severe treatment side effects

Many women being treated for breast cancer suffer from severe treatment side effects even when they don’t receive chemotherapy, a recent study suggests.

One in every 20 Indians suffers from depression

Indians popped in more anti-depressants than ever before in 2016, indicating perhaps that they are now more open to the idea of seeking help for mental health problems.

Wrongly diagnosed foot injury may cause arthritis, chronic pain

The Journal of the American Osteopathic Association Review has highlighted the importance of additional imaging, second opinions for accurate diagnosis and treatment.

Only 1% of R&D funds spent for HIV, TB and malaria: WHO

Investments in health research and development (R&D) are poorly aligned with global public health needs, the World Health Organisation said.

Healthy food may benefit people with HIV, diabetes: Study

Mediterranean diet loaded with fresh fruits and vegetables, lean proteins and healthy fats for six months may benefit people with HIV and Type 2 diabetes.

Cheap breath test may detect stomach, oesophageal cancers

Scientists have developed a cheap and non-invasive test that can measure the levels of five chemicals in the breath to detect cancers of the oesophagus and stomach with 85 per cent accuracy.

source”cnbc”

Nearly 1/2 of breast cancer patients have severe treatment side effects, 1 in 20 Indians suffers from depression

Health weekly roundupHealth weekly roundup

This week was packed with some very shocking yet important health news. To ensure that you don’t miss any, we bring you a weekly roundup. Here is this week’s aggregation of the latest news stories on health, fitness and diet.

Insomnia may triple the risk of asthma: Study

Asthma affects approximately 300 million people worldwide, with major risk factors including smoking, obesity and air pollution.

Mother’s cervical bacteria may help prevent premature birth

The presence of bacteria in a woman’s vagina and cervix may either increase the risk of premature birth or have a protective effect against it, researchers say.

Attention parents! Cooking in those aluminium pans may reduce your kid’s IQ

The findings published in journal Science of the Total Environment, indicate that cadmium is neurotoxic in children and causes kidney damage which is linked to cardiovascular deaths and is carcinogenic.

Eating celery, broccoli can improve treatment of breast cancer

The findings indicate that Luteolin, a naturally occurring, non-toxic plant compound that has been proven effective against several types of cancer.

‘Anxiety, depression may up risk of death from cancers’

Higher levels of anxiety and depression may increase the risk of death from certain cancers, scientists have warned.

Nearly half of breast cancer patients have severe treatment side effects

Many women being treated for breast cancer suffer from severe treatment side effects even when they don’t receive chemotherapy, a recent study suggests.

One in every 20 Indians suffers from depression

Indians popped in more anti-depressants than ever before in 2016, indicating perhaps that they are now more open to the idea of seeking help for mental health problems.

Wrongly diagnosed foot injury may cause arthritis, chronic pain

The Journal of the American Osteopathic Association Review has highlighted the importance of additional imaging, second opinions for accurate diagnosis and treatment.

Only 1% of R&D funds spent for HIV, TB and malaria: WHO

Investments in health research and development (R&D) are poorly aligned with global public health needs, the World Health Organisation said.

Healthy food may benefit people with HIV, diabetes: Study

Mediterranean diet loaded with fresh fruits and vegetables, lean proteins and healthy fats for six months may benefit people with HIV and Type 2 diabetes.

Cheap breath test may detect stomach, oesophageal cancers

Scientists have developed a cheap and non-invasive test that can measure the levels of five chemicals in the breath to detect cancers of the oesophagus and stomach with 85 per cent accuracy.

Protein can cut progression of both inflammatory bowel disease and colon cancer: Study

A new study finds that altering the shape of a protein can significantly reduce the progression of inflammatory bowel disease and colon cancer.

Children exposed to complications at birth are at risk of autism, study finds

A study by Kaiser Permanente found that children who were exposed to complications shortly before or during birth, including birth asphyxia and preeclampsia, were more likely to develop autism spectrum disorder.

source”cnbc”

Eating celery, broccoli can improve treatment of breast cancer

ANI | Jan 25, 2017, 03.30 PM IST

Eating celery, broccoli can improve treatment of breast cancer (Thinkstock photos/Getty Images)Eating celery, broccoli can improve treatment of breast cancer (Thinkstock photos/Getty Images)
Researchers from the University of Missouri found that a natural compound, Luteolin, found in herbs such as thyme and parsley and vegetables such as celery and broccoli, can reduce the risk of developing metastasis originating from triple-negative breast cancer in women.

The findings indicate that Luteolin, a naturally occurring, non-toxic plant compound that has been proven effective against several types of cancer.

“Triple-negative breast cancers are cancer cells that lack three receptors targeted by current chemotherapy regimens. Because of this lack of receptors, common cancer drugs can’t ‘find’ the cells, and doctors must treat the cancer with extremely aggressive and highly toxic treatment strategies,” said Salman Hyder from the College of Veterinary Medicine and the Dalton Cardiovascular Research Center.

“Women with this type of breast cancer also frequently develop metastatic lesions that originate from drug-resistant cells. Therefore, safer therapeutic therapies that are more effective are being sought for this deadly type of cancer in women,” Hyder added.

The team tested Luteolin to determine if it could suppress metastasis, using human triple-negative breast cancer cells grown in mice.

In the first series of tests, they found that Luteolin inhibited the metastasis of triple-negative cancer in the lungs of affected mice.

“Mice exposed to human triple-negative breast cancer cells experienced significantly reduced metastastic growth in their lungs after being treated with Luteolin,” Hyder stated.

“In almost every case, the mice also saw no weight loss, which means luteolin has no toxic effects; this plant compound is both safe and effective,” Hyder explained.

They found that Luteolin inhibits that migration and can also kill cancer cells.

Stay updated on the go with Times of India News App. Click here to download it for your device.

source”cnbc”

Natural Breast Augmentation safe for young mothers

Natural Breast Augmentation safe for young mothersNatural Breast Augmentation safe for young mothers
Natural Breast Augmentation — a procedure where the breasts’ size is increased by transferring fat — is completely safe for young mothers as lactation and other functions are preserved, doctors said on Saturday.

According to the doctors, women desiring to have breast augmentation should opt for the natural way because there is no use of foreign material.

There is no scar or mark left post-operative as the procedure is performed through keyhole, a minimally invasive process.

“The use of silicone implant to enhance the breast size has become passe. In the age where technological devices are becoming nano sized and surgeries becoming minimally invasive, this latest technique of natural breast implantation has gained immense popularity,” said Lokesh Kumar, Director and head of BLK Centre for Plastic and Cosmetic Surgery.

According to medical science, in Natural Breast Augmentation the size and volume of a woman’s breasts is increased using her own body.

The minimally invasive procedure is safe and quick. In a span of a few hours, a woman undergoes from a B to a C cup.

The technique is less stressful on the woman’s body and heals faster.

Additionally, the procedure has the benefit of liposuction where the fat is harvested from areas like abdomen, waist, thighs, back or buttocks.

Kumar said: “This technique is called Beauli and was invented in Germany a few years ago. During the procedure, a very high speed water jet stream is used to separate fat cells from the patient’s body.”

“With the help of a thin metal tube, fat is extracted from areas that are resistant to diet and exercise. Once the fat is loose, it can be collected in a container which is ready to be used in any part of the body for enhancement. Like, for breast augmentation, this fatty tissue is injected under and around the breast area,” said Kumar.

Rakesh Ranjan, a general surgeon from Safdarjung hospital, said: “Today the situation is such that many women are put off with the word ‘silicone’ as there has been a lot of negative publicity due to the use of bad quality implants from unethical sources/surgeons”.

“But the safety of this procedure has stood the test of time. It is simple enough to be carried out as a day care procedure,” he said.

Stating that biologically a woman loses volume in her breasts as she ages, Ranjan said: “This surgery is also for women who possess enough fat in the thighs, abdomen, back, buttocks or arms and want them to get removed, which instead can be used for breasts.”

“Post procedure, the improvement in the breasts is visible only over the next few weeks, as the swelling goes down. One can expect to see marked improvement in breast size and volume as long as the bodyweight does not change,” said Ranjan.

Stay updated on the go with Times of India News App. Click here to download it for your device.

source”cnbc”a

Breast cancer chemotherapy fails to promise relapse-free survival: Study

Breast cancer chemotherapy fails to promise relapse-free survival: StudyBreast cancer chemotherapy fails to promise relapse-free survival: Study
Contrary to expectations, the use of tailored dose-dense chemotherapy in women with high-risk early breast cancerfailed to result in any statistically significant improvement in breast cancer recurrence-free survival, a study has found.

Dose-dense therapy, defined as delivery of chemotherapy at shorter intervals without increasing the cumulative dose, has been suggested as a means to improve efficacy of chemotherapy for early breast cancer.

However, the study led by researchers from Karolinska Institute in Sweden, showed that over a median of 5.3 years the breast cancer recurrence-free survival rates in patients who underwent for tailored dose-dense chemotherapy was 88.7 per cent, whereas those who had standard chemotherapy it was 85 per cent — a difference that was not statistically significant.

Further, patients in the tailored dose-dense group also suffered with non-hematologic toxic effects, such as fatigue, musculoskeletal pain, and neutropenic infection, than patients who took standard adjutant chemotherapy.

Non-hematologic toxic effects were found to occur in 527 (53 per cent) in the tailored dose-dense group and 366 (37 per cent) in the standard adjutant chemotherapy group, the researchers said.

“Although the total treatment time was similar, patients in the tailored dose-dense group underwent more therapy courses and subsequently had more toxic effects, more hospital visits and frequent blood draws,” Jonas Bergh, Professor in Karolinska Institute, was quoted as saying to healio.com.

For the study, appearing in the journal JAMA, the team randomly assigned 2,017 women with high-risk early breast cancer aged 65 years and younger.

Stay updated on the go with Times of India News App. Click here to download it for your device.

 source”cnbc”

New Breast Cancer Cases To Rise To 3.2 Million A Year By 2030

New Breast Cancer Cases To Rise To 3.2 Million A Year By 2030

New Breast Cancer Cases To Rise To 3.2 Million A Year By 2030
India, China have the largest number of women with breast and cervical cancer.
TORONTO: By 2030, the number of women diagnosed every year with breast cancer could almost double to 3.2 million and cervical cancer cases can rise at least 25 per cent to over 700,000 globally unless urgent action is taken, a study has cautioned.

The findings of the study, published in the Lancet, have showed that India and China are two countries with the largest number of women with breast and cervical cancer.

Globally, cervical and breast cancer take the lives of 800,000 women every year — with two-thirds of breast cancer deaths and nine out of 10 cervical cancer deaths occurring in low- and middle-income countries.

Five-year survival after diagnosis for breast cancer ranges from around 50 per cent in South Africa, Mongolia and India, to over 80 per cent in 34 countries, including Australia, the UK, Ireland, France, Germany and the US, highlighting huge inequalities in access to prevention, early detection, and treatment.

Persistent underinvestment in low- and middle-income countries, which receive just 5 per cent of global funding for cancer, has exacerbated the issue.

Further, with many competing health priorities in low- and middle-income countries, services for women’s cancers are given low priority and allocated few resources.
In addition, “there is a widespread misconception that breast and cervical cancers are too difficult and expensive to prevent and treat, particularly in resource-poor countries where the burden of these diseases is highest,” said lead author Ophira Ginsburg, professor at the University of Toronto, Canada.

Yet, breast and cervical cancer are not inevitably fatal and can be prevented and treated, say the authors, particularly if they are detected and treated at an early stage, the researchers observed.

“There are several low-cost, feasible interventions that do not require specialised care in hospital or massive capital investment, and which could be integrated into existing health-care programmes,” explains Lynette Denny, professor at University of Cape Town, South Africa.

Cervical cancer, for example, is almost entirely preventable thanks to cost-effective routine human papillomavirus (HPV) vaccination of girls and cervical screening with treatment of pre-cancers, neither of which require oncologists, or specialist cancer centres, and can prevent 600,000 future cervical cancer deaths in the world’s poorest countries over the next four years.

While mammography and late treatment of breast cancer are likely unaffordable, clinical breast examination screening and breast awareness campaigns are likely to be cost-effective in diagnosing early stage breast cancer in LMICs, and could in turn help promote early treatment.

The response to women’s cancers needs to be seen as a vital part of international commitments to achieve universal health coverage and the new sustainable development goals, the authors said

source”cnbc”

Small Implanted Device Can Fight Breast Cancer

Small Implanted Device Can Fight Breast CancerNEW YORK:  A small device implanted under the skin can improve breast cancer survival by catching cancer cells, slowing the spread of tumours in other organs and allowing time to intervene with surgery or other therapies.

These findings, reported in the journal Cancer Research, suggest a path for identifying metastatic cancer early and intervening to improve outcomes.

Metastatic cancer is a cancer that has spread from the part of the body where it started (the primary site) to other parts of the body, according to American Cancer Society.

“This study shows that in the metastatic setting, early detection combined with a therapeutic intervention can improve outcomes,” said one of the study authors Lonnie Shea from University of Michigan.

The study, done in mice, expands on earlier research from this team showing that the implantable scaffold device effectively captures metastatic cancer cells.

“Currently, early signs of metastasis can be difficult to detect. Imaging may be done once a patient experiences symptoms, but that implies the burden of disease may already be substantial,” Jacqueline Jeruss from University of Michigan’s Comprehensive Cancer Centre.

Improved detection methods are needed to identify metastasis at a point when targeted treatments can have a significant beneficial impact on slowing disease progression,” Jeruss explained.

The device is made of material commonly used in sutures and wound dressings. It is biodegradable and can last up to two years within a patient.

The researchers envision it would be implanted under the skin, monitored with non-invasive imaging and removed upon signs of cancer cell colonisation, at which point treatment could be administered.

The scaffold is designed to mimic the environment in other organs before cancer cells migrate there.

The scaffold attracts the body’s immune cells, and the immune cells draw in the cancer cells.

source”cnbc”

 

Artificial Intelligence can help predict breast cancer risk faster

The team used the AI software to evaluate mammograms and pathology reports of 500 breast cancer patients.The team used the AI software to evaluate mammograms and pathology reports of 500 breast cancer patients.
Researchers have developed anartificial intelligence (AI) software that reliably interprets mammograms, assisting doctors with a quick and accurate prediction of breast cancer risk and thereby helping them do away with unnecessary breast biopsies.

The computer software intuitively translates patient charts into diagnostic information at 30 times human speed and with 99 per cent accuracy, the researchers reported in a paper published online in the journal Cancer.

“This software intelligently reviews millions of records in a short amount of time, enabling us to determine breast cancer risk more efficiently using a patient’s mammogram,” said one of the researchers Stephen Wong from Houston Methodist Research Institute in the US.

“This has the potential to decrease unnecessary biopsies,” Wong noted.

The team used the AI software to evaluate mammograms and pathology reports of 500 breast cancer patients.

The software scanned patient charts, collected diagnostic features and correlated mammogram findings with breast cancer subtype.

Clinicians used results, like the expression of tumour proteins, to accurately predict each patient’s probability of breast cancer diagnosis.

Manual review of 50 charts took two clinicians 50-70 hours. AI reviewed 500 charts in a few hours, saving over 500 physician hours.

Currently, when mammograms fall into the suspicious category, a broad range of three to 95 per cent cancer risk, patients are recommended for biopsies.

Over 1.6 million breast biopsies are performed annually in the US, and about 20 per cent are unnecessarily performed due to false-positive mammogram results of cancer free breasts, estimates the American Cancer Society.

The team hopes this artificial intelligence software will help physicians better define the per cent risk requiring a biopsy, equipping doctors with a tool to decrease unnecessary breast biopsies.

Stay updated on the go with Times of India News App. Click here to download it for your device.

source”gsmarena”